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One type of cannabinoid receptor found in the body. Cannabinoids like THC interact with these receptors to induce some of the subjective and therapeutic effects associated with cannabis. CB1 receptors, to which THC binds readily, are heavily abundant in the brain, which is why you experience a high when consuming cannabis with THC. Natural chemicals produced by the body, like anandamide and 2-AG, also activate CB1 receptors.