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Is a 1:1 & RSO the Same Thing in Ohio?


Cannabis is a complex plant that contains over 500 natural components, of which 104 are cannabinoids. [1] The two most well-known are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD).

  • Δ9-tetrahydrocannabinol (THC), the most popular cannabinoid, is a component of cannabis that provides the psychoactive “high” effect. It is most commonly used to relieve pain, nausea, insomnia, and muscle spasticity. 
  • Cannabidiol (CBD) is the part of the plant that provides plenty of medicinal benefits without the psychoactive “high” you would experience from THC. It is used for a wide range of conditions such as seizures, anxiety, inflammation, and inflammatory bowel disease.

While each cannabinoid present in the cannabis plant provides its own unique effect, together they offer even better benefits with the entourage effect.

The Entourage Effect

The entourage effect is defined as the combined effect of different compounds present in cannabis working together as a whole to provide a greater effect than if working separately. The terpenes, flavonoids, fatty acids, and cannabinoids that are in the cannabis plant all work together to boost the overall benefits given to the consumer. [2]

  • Terpenes are the organic compounds that provide the aromas and flavors of the cannabis plant. They influence the overall effects of cannabis by interacting with the other present components, while enhancing the medicinal benefits.
  • Flavonoids provide color pigmentation, odor, flavor, and protection for the cannabis plant. They are highly pharmacologically active and are being studied further to see the overall benefits they can provide.
  • Fatty Acids are present in the cannabis plant and they help the cannabinoids bind to the CB1 and CB2 receptors.

The entourage effect offers a reality in which the right formulation of cannabis compounds will prove more effective than an isolated compound. [2]

What is a 1:1?

A 1:1 ratio product contains an equal amount of CBD to THC. It is considered to be highly effective for pain relief, fibromyalgia, anxiety, appetite stimulation, and nausea. [3] This ratio is a great starting point for users who are cannabis-naive because the psychoactive effects given from THC are diminished because of the CBD. 

Some of the 1:1 products contain other aspects of the plant, but most of the sublingual oils and capsules available are made with isolated CBD and THC. Both cannabinoids offer their own benefits and complement each other when they are working together; however, without the entire profile of the plant, some argue that it does not provide the best synergistic effects.


Named after its inventor, Rick Simpson Oil (RSO) is a highly concentrated and broad-spectrum cannabis oil that is used by those with very chronic conditions. Since it is a whole plant extract, nothing is added or removed from the plant’s natural composition during the extraction process. RSO is fully activated, meaning that it has been decarboxylated and will be psychoactive without having to heat it up. 

While it was originally created to help with cancer, RSO has been used to relieve symptoms of multiple sclerosis, inflammatory bowel disease, infection, arthritis, and many other debilitating conditions. It is a tar-like substance that has a very pungent taste and smells very similar to the cannabis plant. Because it keeps the plants natural chemical profile, RSO offers full spectrum benefits that induce the entourage effect.

1:1 vs RSO

It is difficult to determine which of these options are better than the other, because they both offer the user different experiences. 1:1 products are typically better for those who have not adapted to the high feeling resulting from THC and are hesitant about getting too strong of effects. Since RSO is full spectrum, the side effects are a bit more intense and should be carefully dosed by those who are inexperienced. 

The Bottom Line

While there has been some research done surrounding the use of cannabis as a medicine, there is still a long way until there is conclusive evidence about which cannabinoid profiles and ratios offer the best results. Each individual will have a unique experience to every chemical formulation of the cannabis plant species, so it is important to understand that what works best for one individual might not be the best option for someone else with the same condition. 

 If you are interested to see if medical marijuana could offer you relief, take this quick survey to determine if you pre-qualify. Our team of highly-trained and compassionate physicians at DocMJ Doctors Marijuana are available across the state to guide patients on their medical cannabis journey. 

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/


[3] https://healer.com/cbd-cannabis-dosage-guide-project-cbd-interview-with-dr-sulak/

[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001746/

[5] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143706/

[6] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570572/

[7] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/

[8] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736954/